Methoxylated Cinnamic Esters with Antiproliferative and Antimetastatic Effects on Human Lung Adenocarcinoma Cells

Lung cancer is the leading cause of mortality worldwide, and malignant melanomas are highly lethal owing to their elevated metastatic potential. Despite improvements in therapeutic approaches, treatments not completely effective. Thus, new drug candidates continuously sought. We synthesized mono- di-methoxylated cinnamic acid esters investigated antitumor A cell viability assay was performed identify promising substances against A549 (non-small-cell lung cancer) SK-MEL-147 (melanoma) cells. (E)-2,5-dimethoxybenzyl 3-(4-methoxyphenyl)acrylate (4m), a monomethoxylated derivative, identified as lead compound, its potential deeply investigated. Various approaches were employed investigate antiproliferative (clonogenic cycle analysis), proapoptotic (annexin V assay), antimigratory (wound-healing adhesion assays) activities 4m on In addition, western blotting explore mechanism action. demonstrated that inhibits proliferation by promoting cyclin B downregulation arrest at G2/M. Antimigratory also observed. The involved ability modulate mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway once phosphorylated-ERK expression considerably reduced response treatment. Our findings demonstrate anticancer candidate.